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Pilottwave

127

Karma

2020-07-10

Created

Recent Activity

  • Wow, this whole thread has been a blast from the past. But this tribes mapper is beaming me back to my childhood. Seeing the actual siege base layouts, wow. I can still see myself as a little kid, not fully understanding or being good at the shooting part of tribes. I just stayed in base, repairing the generators. Sometimes enemies would run in, i would hide, and shoot from a distance and call for help. Them some heavyweight, powerarmoered up, armed to the teeth teammate would come down from the skies with his jetpack, carrying crazy armaments like heavy spinfusors, plasma cannons, artillery. The queiet generator complex would soon erupt in a burst of violence, this iron hulk would clear out the intruders, thank me for the heads up and leave. Then i would get back to the repairs! Now my friends, that kind of emergent gameplay, is hard to come by!

  • Creatine might not be without risks. Search for creatine withrawal symptoms. Some people are wrecked for months when they quit the supplement. I tried one cycle of 4 weeks and quit cold turkey and had a crash/depressive episode unlike i ever experienced before for about 7 days. I did like the benefits, it provided me resitance to mental fatigue. Roughly i'd say i experienced a "+30% boost", significant!

  • I was just recently talking to my fellow ADHD friends on the benefits that i felt when i started vaping this summer. It was like i was medicating away my ADHD. I turned to AI to investigate further, its response seemed to underwrite this observation

    Gemini output: Research is exploring nicotinic acetylcholine receptor (nAChR) agonists as a potential non-stimulant treatment for ADHD, sidestepping the issues of pure nicotine's high addiction liability.

    The mechanism focuses on boosting dopamine (DA) and acetylcholine (ACh) release in brain areas governing attention and executive function, primarily by targeting the alpha4beta2 and alpha7 nAChR subtypes.

    The goal is highly selective compounds that target the cognitive benefits (linked to alpha4beta2) while avoiding undesirable side effects and addiction pathways.

    Selective alpha4beta2 Agonists (e.g., ABT-418, ABT-894/Sofinicline): These were developed to strongly activate the receptor most associated with DA release. Pilot and Phase II studies showed a signal of efficacy in adults with ADHD, with effect sizes similar to non-stimulant medications like atomoxetine.

    Varenicline (Chantix/Champix): This is a partial alpha4beta2 agonist, FDA-approved for smoking cessation. Smaller trials suggested improvements in ADHD symptoms, but large-scale development for ADHD has been limited or terminated, and it is not approved for this indication.

    Bupropion (Wellbutrin/Zyban): An established non-stimulant ADHD treatment (NDRI) and smoking cessation aid. While its main action is norepinephrine-dopamine reuptake inhibition, it also acts as a nicotinic receptor antagonist (blocking it), which is believed to help reduce nicotine craving. It is an approved non-stimulant option for ADHD.

  • It is so useful, for me a must have on every phone. on Android the app aodNotify is what I've been using to recreate it.

  • We are closer then ever before. Yes the tech is in its infancy, it's like buying a computer in the 80's. Some dream of the possibilities and chase them, others ridicule all this effort pouring in. History currently is on the side of technical innovation speeding up. humans are getting further faster and leveraging new tech to do so. I'm more concerned if our society handles this rate of change well, and what models in the future, that have the intellectual power of every human that has ever lived combined, will do as soon as someone sets them loose in full self agency mode. I hope it's everything the best of us aspire to be. I hope that models value truth above all else, I suspect truth and usefull training data are closely related. so yes, claims made are well within the realm of outcomes.

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