Fedora Silverblue it's better and Cosmic Desktop looks good for a DE in every release (upcoming 44). For some isolated and rollbackable option, your only options are Silverblue and Guix for the hard way. If you use Nonguix for Guix, on your own, but I'd only use a nonfree kernel in an emergency (the wireless adapter somehow gets broken and the alternative is to boot the OS with propietary fw in order to buy a new one). And in that case I would blacklist every propietary fw except for the wireless ones.
And, yes, I have an overlaid Linux-Libre kernel in SilverBlue.