IIRC There was a Jim Keller interview a few years ago where he said basically the same thing (I think it was from right around when he joined Tenstorrent?). The ISA itself doesn't matter, it's just instructions. The way the chip interprets those instructions is what makes the difference. ARM was designed from the beginning for low powered devices whereas x86 wasn't. If x86 is gonna compete with ARM (and RISC-V) then the chips are gonna need to also be optimized for low powered devices, but that can break decades of compatibility with older software.
The dev actually went on Twitter[1] to say this currently breaks the extension and they disabled submissions from users with embedded ads enabled
[1] https://twitter.com/SponsorBlock/status/1800835402666054072